Haematology Watch

MACROCYTIC ANAEMIA


Megaloblastic anaemia:

Folate deficiency

Vitamin B12 deficiency

Drugs- and Toxin-induced disorders of DNA synthesis:

    Folate anatagonism (Methotrexate)

    Purine antagonism (6-Mercaptopurine)

    Pyrimidine antagonism (Cytosine arabinoside)

    Alkylating agents (Cyclophosphamide)

    Trimethoprim

    Oral contraceptives

    Arsenic

Inherited disorders of DNA synthesis:

    Homocystinuria

    Methylmalonic aciduria

    Thiamine-responsive megaloblastic anaemia

    Lesch-Nyhan syndrome

    Transcobalamin II deficiency

    Orotic aciduria


Non-Megaloblastic anaemia:

Associated with accelerated haemopoiesis:

    Haemolysis

    Haemorrhage

Other causes:

    Aplastic anaemia

    Myelodysplastic syndrome

    Inherited sideroblastic anaemia: Pearson syndrome

    CDA tye I and III

    Diamond-Blackfan Anaemia

    Liver disease

    Hypothyroidism