IRON-DEFICIENCY ANAEMIA
LOW INTAKE:
Vegeterians
NORMAL INTAKE:
With malabsorption:
Achlorhydria
Gastrectomy
Autoimmune gastritis
Drugs increasing gastric pH
Duodenal bypass
Tannins
Phytates
Bran
Coeliac sprue
With normal absorption:
-With haemorrhage: (Most common mechanism)
Gatrointestinal (Peptic ulcer, Gastritis, Salicylates, Hook worm infestation, Varices, Neoplasms, Haemorrhoids)
Uterine (Leiomyoma uteri, CA endometrium, others)
Urinary (Urolithiasis, Neoplasms, Cyclophosphamide, Schistosomiasis)
Pulmonary (Bronchiectasis, Tuberculosis, Pulmonary haemosiderosis)
Coagulopathies
Diagnostic phlebotomies in neonates
Self-inflicted haemorrhage
-Without haemorrhage:
Reduced iron uptake of erythron:
Atransferrinemia
Anti-transferrin receptor antibody
Normal iron uptake of erythron in high demand-to-supply state:
Pregnnacy
Premature neonates
Puberty
Lactation
Erythropoietin therapy
Polycythemia vera