MACROCYTIC ANAEMIA
Megaloblastic anaemia:
Folate deficiency
Vitamin B12 deficiency
Drugs- and Toxin-induced disorders of DNA synthesis:
Folate anatagonism (Methotrexate)
Purine antagonism (6-Mercaptopurine)
Pyrimidine antagonism (Cytosine arabinoside)
Alkylating agents (Cyclophosphamide)
Trimethoprim
Oral contraceptives
Arsenic
Inherited disorders of DNA synthesis:
Homocystinuria
Methylmalonic aciduria
Thiamine-responsive megaloblastic anaemia
Lesch-Nyhan syndrome
Transcobalamin II deficiency
Orotic aciduria
Non-Megaloblastic anaemia:
Associated with accelerated haemopoiesis:
Haemolysis
Haemorrhage
Other causes:
Aplastic anaemia
Myelodysplastic syndrome
Inherited sideroblastic anaemia: Pearson syndrome
CDA tye I and III
Diamond-Blackfan Anaemia
Liver disease
Hypothyroidism